So, I have a thyroid nodule. Now what?
November 17th, 2009Thyroid nodules are actually pretty common. If an ultrasound was performed on randomly selected people, up to 67% of them would be found to have a nodule, according to the American Thyroid Association. Nodules are more common in women and older people. Cancer can occur in 5-10% of nodules, depending on other risk factors, and it is important to be able to identify the ones with cancer. A history of radiation exposure and a family history of thyroid cancer are two factors that increase the risk that a person’s nodule is cancerous.
If a nodule is felt or suspected, an ultrasound of the thyroid is usually one of the first diagnostic studies obtained. This is an easy test to undergo and requires no specific preparation. This test can give very good information about the nature of the nodule including the size, whether it is fluid-filled or solid, if there are calcifications, and other details. In general, only nodules larger than 1 cm should be evaluated further. Occasionally, smaller nodules require additional evaluation because of suspicious ultrasound findings or risk factors for thyroid cancer.
A serum TSH (thyroid stimulating hormone) should be checked in everyone with a suspected nodule 1 cm in size or larger. A significantly reduced level would prompt the need for a radionuclide thyroid scan to determine if the nodule is over-functioning. If so, it is unlikely that the nodule is a cancer and no biopsy would be necessary at that time. Additional work up might be indicated, however, in terms of the function of the thyroid.
Fine needle aspiration biopsy (FNA), often performed with ultrasound guidance, is the best method for evaluating nodules 1-1.5 cm in size or larger. The possible results include a benign, non-diagnostic, indeterminate, or malignant biopsy. A benign nodule should be followed with repeat physical exam or ultrasound in 6-18 months and a repeat biopsy for significant growth. Non-diagnostic results should undergo a repeat biopsy. Repeated non-diagnostic results would often require surgery to make the diagnosis. For indeterminate results, either further imaging or surgery is recommended depending on the details of the biopsy. For malignant results, surgery is recommended.
Surgery for thyroid nodules includes thyroid lobectomy (removing essentially 1/2 of the thyroid gland), sub-total or total thyroidectomy. The extent of surgery is based on your clinical picture, size and number of nodules, and on the results of a “frozen section” analysis of the thyroid immediately upon removal. This is done while you are in the operating room and is basically a quick look at the specimen by a pathologist to determine if it is cancer. Sometimes, cancer can be definitively diagnosed, and this would alter the surgery to be performed.
Hopefully, this has given you a little overview of the management of thyroid nodules. If you and your doctor have determined that you need further work up, please call our office and we would be happy to schedule a time for you to come in for a consultation.

